Description

view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008;

In the past two decades, the large investment in cancer research led to identification of the complementary roles of genetic mutation and epigenetic change as the fundamental drivers of cancer. With these discoveries, we now recognize the deep heterogeneity in cancer, in which phenotypically similar behaviors in tumors arise from different molecular aberrations. Although most tumors contain many mutations, only a few mutated genes drive carcinogenesis. For cancer treatment, we must identify and target only the deleterious subset of aberrant proteins from these mutated genes to maximize efficacy while minimizing harmful side effects.

Together, these observations dictate that next-generation treatments for cancer will become highly individualized, focusing on the specific set of aberrant driver proteins identified in a tumor. This drives a need for informatics in cancer research and treatment far beyond the need in other diseases. For each individual cancer, we must find the molecular aberrations, identify those that are deleterious in the specific tumor, design and computationally model treatments that target the set of aberrant proteins, track the effectiveness of these treatments, and monitor the overall health of the individual. This must be done efficiently in order to generate appropriate treatment plans in a cost effective manner. State-of-the-art techniques to address many of these needs are being developed in biomedical informatics and are the focus of this volume.

LangueenVersionBrochéDate de sortie initiale26 novembre 2014Nombre de pages374IllustrationsNon

Personnes impliquées

Auteur principal

Michael F. Ochs

Deuxième auteur

John T. Casagrande

Rédacteur en chef

Michael F. Ochs

Deuxième rédacteur

John t. Casagrande

Editeur principal

Springer-Verlag New York Inc.

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Nom du fabricantSpringer Nature Customer Service Center GmbHAdresse du fabricantEuropaplatz 3 | 69115| Heidelberg| DEAdresse électronique du fabricant[email protected]Informations sur le fabricantLes informations du fabricant ne sont actuellement pas disponibles

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Médecine et Soins infirmiers

Médecine générale

Médecine clinique et Interne

Recherche médicale

Maladies et Troubles

Oncologie

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